Free calculator · Dissolution
Dissolution Calculator
Turn your vessel responses into % dissolved and get the USP <711> stage verdict: S1, S2 or S3.
- USP <711> S1/S2/S3
- HPLC and UV-Vis
- 6, 12 or 24 units
- No sign-up
How to use
Four steps, or fewer
- Enter the standard preparation and its responses.
- Enter the medium volume, any sample dilution, the label claim and Q from the monograph.
- Paste the response of each unit. Enter 6 units for S1, all 12 for S2 or all 24 for S3.
Not sure what to enter? Press Load example to see the calculator with realistic data. Your inputs are saved in this browser, so they are still there when you come back.
Theory & criteria
How % dissolved and the stages are calculated
% dissolved = (A_unit / Ā_std) × C_std × DF × V_medium / label claim × 100
USP <711> acceptance table (immediate release)
| Stage | Units | Criteria |
|---|---|---|
| S1 | 6 | Each unit not less than Q + 5% |
| S2 | 6 more (12) | Average of 12 ≥ Q and no unit less than Q − 15% |
| S3 | 12 more (24) | Average of 24 ≥ Q, not more than 2 units less than Q − 15%, and no unit less than Q − 25% |
Modified-release and delayed-release products have different acceptance tables. Use the Dissolution Profile calculator for multi-point profiles with volume correction.
References
- USP General Chapter <711> Dissolution
- Ph. Eur. 2.9.3 Dissolution test for solid dosage forms
These calculators are decision support for orientation and training. They are not validated GMP software, and results must be checked against your approved method, SOP and the current pharmacopoeia or guideline before use in GMP records. Your data is processed in your browser and is not sent to Molgenium.