Dissolution Profile Calculator
Calculate a multi-point dissolution profile, corrected for the drug removed with every sample you withdraw.
- Volume correction
- Replaced or not replaced
- Profile chart
- No sign-up
Four steps, or fewer
- Enter the standard preparation and its responses.
- Enter the medium volume, the volume withdrawn at each pull and whether it is replaced.
- Paste the time points with their responses. The chart shows the corrected and uncorrected profile.
Not sure what to enter? Press Load example to see the calculator with realistic data. Your inputs are saved in this browser, so they are still there when you come back.
Why volume correction matters
Every sample you withdraw removes dissolved drug from the vessel. Without correction, later time points are underestimated, typically by 1–2% over a six-point profile.
Medium replaced: amountᵢ = Cᵢ × V + v × Σ C_j (j < i)
Not replaced: amountᵢ = Cᵢ × (V − (i − 1) × v) + v × Σ C_j (j < i)
% dissolvedᵢ = amountᵢ / label claim × 100
Use the corrected profile for comparisons with the f2 Similarity calculator.
References
- USP General Chapter <1092> The dissolution procedure: development and validation
- FDA Guidance: Dissolution testing of immediate release solid oral dosage forms (1997)
These calculators are decision support for orientation and training. They are not validated GMP software, and results must be checked against your approved method, SOP and the current pharmacopoeia or guideline before use in GMP records. Your data is processed in your browser and is not sent to Molgenium.