Accuracy (Recovery) Calculator
Calculate % recovery for every spiked preparation, the mean and %RSD per level and the overall recovery.
- ICH Q2(R2)
- Peak area or amount found
- Per-level statistics
- No sign-up
Four steps, or fewer
- Choose whether you enter peak areas or amounts found.
- For peak areas, enter the standard concentration and responses.
- Paste each preparation: level, amount added and area (or found).
Not sure what to enter? Press Load example to see the calculator with realistic data. Your inputs are saved in this browser, so they are still there when you come back.
How recovery is calculated
Recovery (%) = found / added × 100
ICH Q2(R2) recommends at least nine determinations over at least three levels covering the range, for example three preparations at each of 80, 100 and 120%. Typical drug product assay criteria are a mean recovery of 98.0–102.0% at each level with a %RSD of ≤ 2.0%. Impurity methods use wider ranges.
References
- ICH Q2(R2) Validation of analytical procedures
- USP General Chapter <1225>
These calculators are decision support for orientation and training. They are not validated GMP software, and results must be checked against your approved method, SOP and the current pharmacopoeia or guideline before use in GMP records. Your data is processed in your browser and is not sent to Molgenium.